This research aims to present a multi-scale framework for predicting the overall mechanical responses of semi-crystalline matrix composites at high levels of ductile damage. The polymer matrix phase, depending on the environmental conditions, exhibits nonlinear inelastic mechanisms accompanied by ductile damage, and the reinforcements are considered as elastic materials. In the semi-crystalline matrix composites, severely damaged regions exhibit material softening. This leads to early failures due to damage localization, and non-physical and mesh-sensitive responses in typical local computational models. To address this, a nonlocal gradient-enhanced approach is introduced into the multi-scale framework [1]. To this end, different scenarios for the size of the non-local length scale versus the size of the Representative Volume Element (RVE) are discussed. As a result, an appropriate homogenization framework is presented that determines how the stress equilibrium and the nonlocal equations appear at the micro- and macro-scales. To homogenize the composite structure, Mori-Tanaka Transformation Field Analysis (TFA) is implemented in the commercial software ABAQUS using a user-defined material subroutine [2]. The accuracy of the present nonlocal multi-scale model is first evaluated by comparing the results obtained from a full-structure multi-layered composite. Then, a parametric study is performed to examine the efficiency of the proposed model in capturing the material behavior in highly damaged areas and to explore the effects of non-local parameters on the mechanical responses. The results clearly show that the present nonlocal multiscale model is efficient in dealing with the computational instabilities in the heavily damaged areas when the non-local approach is implemented at the macro scale.