In offshore geotechnical engineering, appropriate modelling of structure-soil interaction is an important but challenging aspect. The key to the contact simulation is to reasonably capture both the effective stress from soils and the water pore pressure at the structure-soil interface. This is especially true for uplifting modelling. When structures are lifted off the seabed, the interface underneath the structures is possibly open and negative excess pore pressure is generated and meanwhile dissipated. This cannot be captured by traditional mechanical interfaces, and the so-called coupled hydro-mechanical interfaces, describing both mechanical and hydraulic behaviour, are needed. This paper overviews three types of such interfaces, i.e., Interface C, Interface W and Interface G. The first one is a contact controlled by penalty method, while the latter two are formulated as elements with the difference being whether the interface is treated as a layer of ‘water’ elements or ‘gap’ elements. An example of uplifting a surface footing off clay seabed is presented to illustrate the capabilities of these interfaces in uplifting problems. Compared with physical modelling results from centrifuge tests, recommendations are provided for uplifting modelling in offshore geotechnical engineering.