COMPLAS 2023

Pharmaceutical Powder Compaction Analysis by the Drucker-Prager/Cap Model with Density Related Mechanical Behaviour

  • Ishikawa, Satoshi (IDAJ Co., LTD.)
  • Mizunaga, Daisuke (Otsuka Pharmaceutical Co., Ltd.)

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The forming process of the pharmaceutical powder tablet has the major problem such as cracking, chipping, and adhering. In order to solve this large deformation problem, many literatures use the Finite Element Method with Drucker-Prager constitutive model expanded with the cap surface at the compressive zone. For example, Michrafy et al. indicated the DPC material parameters on the two dimensional axisymmetric FEM model. While Furukawa et al. showed the DPC model which has the dependency of the relative density, because, the pharmaceutical powder has taken strong nonlinear behaviour. In this paper, we implemented the relative density dependent DPC model on the commercial FEM code Abaqus by using user subroutine technique. Also this paper studied various conditions such as the friction coefficient, loading and model shapes, etc. Furthermore, we explored differences between the experiment and the numerical result. Our proposed method can help the analysis of process of pharmaceutical power and the estimation of cracking.